1412439-03-2

Upstream product

• 1412439-02-1 methyl (δR,1R,3aS,4E,7R,7aR)-4-{(2Z)-2-{(3S,5R)-3,5-bis{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-methylenecyclohexylidene}ethylidene}octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate 
• 75-16-1 methylmagnesium bromide 
• 1412438-97-1 7-((3R,3aR,4R,7S,7aR)-octahydro-3-[(1S)-2-iodo-1-methylethyl]-3a-methyl-1H-indene-4-yl)-α,α-dimethylheptanol 
• 1412438-98-2 methyl (δR,1R,3aR,4S,7R,7aR)-octahydro-4-hydroxy-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate 
• 1412438-99-3 methyl (δR,1R,3aR,7R,7aR)-octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-4-oxo-1H-indene-1-pentanoate 
• 1412439-00-9 methyl (δR,1R,3aR,4E,7R,7aR)-4-(bromomethylene)octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl-1H-indene-1-pentanoate 
• 1412439-01-0 methyl (δR,1R,3aS,4E,7R,7aR)-octahydro-7-(7-hydroxy-7-methyloctyl)-δ,7a-dimethyl4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-1H-indene-1-pentanoate 

Downstream Products

• 1412439-04-3 (1R,3S,5Z)-4-methylene-5-{(2E)-2-{(1R,3aS,7R,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7-(7-hydroxy-7-methyloctyl)-7a-methyl-4H-inden-4-ylidene}ethylidene}cyclohexane-1,3-diol 

Relevant academic research and scientific papers

Synthesis of (1α)-1,25-dihydroxyvitamin D3 with a β-positioned seven-carbon side chain at C(12)

A convergent synthesis of an analogue of (1α)-1,25-dihydroxyvitamin D3 (1b) with a C7 side chain at C(12), i.e., of 5 (Fig.), is described. A key step of the synthesis is the assembly of the triene system by a PdII-catalyzed ring closure of an enol triflate ('bottom' fragment) followed by coupling of the resulting PdII intermediate with an alkenylboronate ('upper' fragment) (Scheme 2). The synthetic strategy allows isotopic labelling at the end of the synthesis. Copyright