1412838-22-2Relevant academic research and scientific papers
Asymmetric and diastereoselective Mannich reactions using hydantoin as a chiral auxiliary
Li, Xuan-Ran,Lu, Cui-Fen,Chen, Zu-Xing,Li, Yan,Yang, Gui-Chun
, p. 1380 - 1384,5 (2020/09/16)
The Mannich reaction of titanium enolates of a chiral hydantoin with various aldimines smoothly occurred in good yields and with high anti-diastereoselectivity. The Mannich adducts can be readily cleaved by alcoholysis to afford several β-amino ester derivatives in good yields and in almost enantiomerically pure form.
