141306-66-3

Usage

Molecular weight

284.28 g/mol

Structure

Indole-2-carboxylic acid derivative with a 4-fluorophenyl group

Type of compound

Heterocyclic organic compound

Usage

Synthesis of pharmaceuticals and agrochemicals

Potential applications

Medicine, agriculture, and material science

Importance

Valuable building block for drug and agrochemical development, versatile intermediate in organic synthesis

Upstream product

• 100-63-0 phenylhydrazine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 91348-45-7 3-bromo-1H-indole-2-carboxylic acid ethyl ester 
• 3770-50-1 2-carbethoxyindole 
• 122255-02-1 methyl 2-(4-fluorobenzyl)-3-oxobutanoate 
• 161038-68-2 4-fluoro-α-oxobenzenepropanoic acid ethyl ester 
• 93957-39-2 3-(4-Fluorophenyl)-1H-indole-2-carboxylic acid,ethyl ester 
• 141306-65-2 methyl 3-(4-fluorophenyl)-1H-indole-2-carboxylate 

Downstream Products

• 101125-32-0 3-(4-fluorophenyl)-1H-indole 
• 161038-73-9 3-(4-fluorophenyl)-1H-indole-2-carboxylic acid phenylmethyl ester 
• 141306-20-9 3-(4-Fluorophenyl)-1-(4-piperidyl)-1H-indole 
• 141306-13-0 3-(4-fluorophenyl)-1-(4-pyridinyl)-1H-indole 
• 161038-74-0 3-(4-fluorophenyl)-α-methyl-2-<(phenylmethoxy)carbonyl>-1H-indole-1-acetic acid ethyl ester 
• 161038-75-1 2-carboxy-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid ethyl ester 
• 161038-77-3 3-(4-fluorophenyl)-2-hydroxymethyl-α-methyl-1H-indole-1-acetic acid ethyl ester 

Relevant academic research and scientific papers

BACTERIAL EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Fused lactones as a route to functionalized 1-substituted indoles

Indole lactones 8 and 14 were synthesized as a means of functionalizing the 1-isopropyl substituent of the indole nucleus. Lactone 8, upon reduction with diisobutylaluminum hydride, produces lactol 9 which behaves like a masked hydroxy aldehyde and underg

Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2. Substituted 3-(4-Fluorophenyl)-1H-indoles

A series of 3-(4-fluorophenyl)-1H-indoles substituted in the 1-position with 4-piperidinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperazinyl was synthesized. By variation of the substituents in the benzene part of the indole nucleus in 1-2-4-3-(4-fluo