1413176-63-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 153046-00-5 (R)-methyl 3-hydroxy-2-(4-methoxybenzylamino)propanoate 

Downstream Products

• 1413176-65-4 (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(4-methoxybenzyl)carbamate 
• 1413176-67-6 (S)-1-(tert-butyldimethylsilyloxy)-N-(4-methoxybenzyl)but-3-en-2-amine 
• 1413176-70-1 tert-butyl (S)-allyl((1-(tert-butyldimethylsilyloxy)but-3-en-2-yl)(4-methoxybenzyl)carbamoyl)carbamate 
• 1413176-84-7 (S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate 

Relevant academic research and scientific papers

A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors

A variety of diazepinone derivatives were prepared from α-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3, 4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (Ki = 145.97 ± 4.87 nM) against human cytidine deaminase.