153046-00-5

Upstream product

• 2104-89-4 D-serine methyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 

Downstream Products

• 936362-74-2 (4R)-N-(p-methoxybenzyl)-2,2-dioxo-1,2,3-oxathiazolidine-4-carboxylic acid methyl ester 
• 1413176-65-4 (S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(4-methoxybenzyl)carbamate 
• 1413176-67-6 (S)-1-(tert-butyldimethylsilyloxy)-N-(4-methoxybenzyl)but-3-en-2-amine 
• 1413176-70-1 tert-butyl (S)-allyl((1-(tert-butyldimethylsilyloxy)but-3-en-2-yl)(4-methoxybenzyl)carbamoyl)carbamate 
• 1413176-84-7 (S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate 
• 1413176-63-2 methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate 
• 231291-91-1 (E)-(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzylamino)-octadec-4-en-3-one 
• 231291-93-3 ((E)-(S)-1-Hydroxymethyl-2-oxo-heptadec-3-enyl)-(4-methoxy-benzyl)-carbamic acid tert-butyl ester 
• 231291-87-5 (E)-1-[(S)-3-(4-Methoxy-benzyl)-2,2-dimethyl-oxazolidin-4-yl]-hexadec-2-en-1-one 
• 231291-81-9 (E)-(2S,3S)-2-(4-Methoxy-benzylamino)-octadec-4-ene-1,3-diol 
• 231291-79-5 (E)-(2S,3R)-2-(4-Methoxy-benzylamino)-octadec-4-ene-1,3-diol 
• 231291-85-3 {2-[(S)-3-(4-Methoxy-benzyl)-2,2-dimethyl-oxazolidin-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Total Synthesis of (+)-Hyacinthacine A1Using a Chemoselective Cross-Benzoin Reaction and a Furan Photooxygenation-Amine Cyclization Strategy

We report the shortest synthesis of glycosidase inhibitor (+)-hyacinthacine A1 using a highly chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reaction as well as a furan photooxygenation-amine cyclization strategy. This is the first such cyclization on a furylic alcohol, an unprecedented reaction due to the notorious instability of the formed intermediates. The photooxygenation strategy was eventually incorporated into a three-step one-pot process that formed the requisite pyrrolizidine framework of (+)-hyacinthacine A1.

A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors

A variety of diazepinone derivatives were prepared from α-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3, 4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (Ki = 145.97 ± 4.87 nM) against human cytidine deaminase.

A concise stereoselective synthesis of orthogonally protected lanthionine and β-methyllanthionine

Lantibiotics such as nisin are active against most Gram-positive bacteria and constitute an important class of antibacterial agents. These ribosomally synthesized peptides contain either one or both of the unusual amino acids meso-lanthionine (m-Lan) or β

Stereoselective synthesis of β-amino alcohols: Practical preparation of all four stereomers of N-PMB-protected sphingosine from L- and D-serine

Serine was efficiently converted to the N-p-methoxybenzyl (PMB) protected α'-amino enone derivative 6, which was reduced with Zn(BH4)2 to the corresponding anti-β-amino alcohol in >96% de. On the other hand, N- PMB-N-Boc-protected α'-amino enone derivative 8 was reduced by NaBH4 to syn-product with a diastereoselectivity of ca. 90%.