141318-53-8

Basic information

• Product Name: (3S,4R)-3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one
• CAS NO: 141318-53-8
• Molecular Weight: 565.709
• Mol File: 141318-53-8.mol

Chemical Properties

• CAS DataBase Reference: (3S,4R)-3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one(141318-53-8)
• EPA Substance Registry System: (3S,4R)-3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one(141318-53-8)

Safety Data

• Hazardous Substances Data: 141318-53-8(Hazardous Substances Data)

Upstream product

• 130115-06-9 (R)-methyl 2-tert-butoxy-2-phenylacetate 
• 130115-08-1 (R)-2-t-butoxy-2-phenylpropanal 
• 19810-31-2 Benzyloxyacetyl chloride 
• 130115-18-3 [Bis-(4-methoxy-phenyl)-methyl]-[(R)-2-tert-butoxy-2-phenyl-eth-(E)-ylidene]-amine 
• 20698-91-3 (R)-methyl mandelate 
• 19293-62-0 p,p'-dimethoxybenzhydrylamine 

Downstream Products

• 130115-10-5 (2R,3S,4R)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester 
• 130115-12-7 (4R,5R)-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone 
• 119660-39-8 isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate 
• 119642-26-1 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester 

Relevant articles and documents

A Stereoselective Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxybutyric Acid Derivatives, the Key Components of a Renin Inhibitor and Bestatin

The title synthesis was achieved by featuring the -cycloaddition reaction of benzyloxyketene with a chiral imine derived from methyl (R)- or (S)-mandelate, alcoholysis of the formed 3,4-cis disubstituted β-lactam under acidic conditions, and reductiv

A novel synthesis of the (2R,3S)-and (2S,3R)-3-amino-2-hydroxycarboxylic acid derivatives, the key components of a renin inhibitor and bestatin, from methyl (R)- and (S)-mandelate

The title synthesis could be accomplished by featuring the [2+2]-cycloaddition reaction of a chiral imine with benzyloxyketene, alcoholysis of the formed 2-azetidinone derivative, and reductive removal of the mandelate-derived benzylic oxygen by way of a 2-oxazolidone derivative.