130115-06-9

Upstream product

• 20698-91-3 (R)-methyl mandelate 
• 115-11-7 isobutene 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 130115-08-1 (R)-2-t-butoxy-2-phenylpropanal 
• 119642-26-1 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester 
• 130115-19-4 Benzyl-[(R)-2-tert-butoxy-2-phenyl-eth-(E)-ylidene]-amine 
• 130115-18-3 [Bis-(4-methoxy-phenyl)-methyl]-[(R)-2-tert-butoxy-2-phenyl-eth-(E)-ylidene]-amine 
• 130115-13-8 (4R,5R)-1-benzyl-5-<(R)-(1-benzyloxy-1-isopropoxycarbonyl)methyl>-4-phenyl-2-oxazolidone 
• 119660-39-8 isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate 
• 121506-22-7 (2R,3S)-nor-C-statine hydrochloride 
• 141318-54-9 (3S,4R)-1-Benzyl-3-benzyloxy-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one 
• 130115-22-9 (3R,4R)-1-benzyl-3-benzyloxy-4-<(R)-1-(t-butoxy)benzyl>-2-azetidinone 
• 130115-21-8 (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butoxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone 
• 141318-53-8 (3S,4R)-3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one 
• 130115-11-6 isopropyl (2R,3S,4R)-3-benzylamino-2-benzyloxy-4-hydroxybutyrate 
• 141280-91-3 isopropyl (2R,3S)-3-acetamido-2-acetoxy-4-cyclohexylbutyrate 

Relevant academic research and scientific papers

Chiral thiols: The assignment of their absolute configuration by 1H NMR

A general NMR spectroscopy protocol for determination of absolute configuration of thiols, that includes the introduction of new aryl-tert-butoxyacetic acids as chiral derivatizing agents (CDAs), is described.

A Stereoselective Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxybutyric Acid Derivatives, the Key Components of a Renin Inhibitor and Bestatin

The title synthesis was achieved by featuring the -cycloaddition reaction of benzyloxyketene with a chiral imine derived from methyl (R)- or (S)-mandelate, alcoholysis of the formed 3,4-cis disubstituted β-lactam under acidic conditions, and reductiv

A novel synthesis of the (2R,3S)-and (2S,3R)-3-amino-2-hydroxycarboxylic acid derivatives, the key components of a renin inhibitor and bestatin, from methyl (R)- and (S)-mandelate

The title synthesis could be accomplished by featuring the [2+2]-cycloaddition reaction of a chiral imine with benzyloxyketene, alcoholysis of the formed 2-azetidinone derivative, and reductive removal of the mandelate-derived benzylic oxygen by way of a 2-oxazolidone derivative.