14135-68-3

Usage

Type of compound

Synthetic chemical compound

Structure

Ketone derivative with a morpholine ring attached to a diphenylethanone structure

Potential applications

Pharmaceutical intermediate, being studied for potential biological activities

Importance

Valuable building block for the synthesis of various organic compounds

Safety precautions

Handle with proper safety precautions and in accordance with all applicable regulations
These properties and contents provide a comprehensive overview of 1-(morpholin-4-yl)-2,2-diphenylethanone, highlighting its chemical structure, potential uses, and the importance of handling it safely.

Upstream product

• 110-91-8 morpholine 
• 117-34-0 2,2-diphenylacetic acid 
• 1696-20-4 4-acetylmorpholine 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 4467-90-7 N-hydroxy-2,2-diphenylacetimidoyl chloride 
• 81838-55-3 1-Morpholin-4-yl-2,2-diphenyl-ethanone oxime 
• 591-50-4 iodobenzene 

Relevant academic research and scientific papers

Amide formation using in situ activation of carboxylic acids with [Et 2NSF2]BF4

The formation of amides through the in situ activation of carboxylic acids with [Et2NSF2]BF4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99 % yield. The reaction of hindered amines was also possible in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react without racemization. Copyright

A Study of the Ferrous Ion-initiated SRN1 Reactions of Halogenoarenes with tert-Butyl Acetate and N-Acylmorpholine Enolates

A detailed preparative study is reported of the ferrous ion-initiated SRN1 reactions of a range of halogenoarenes with the sodium enolates of tert-butyl acetate, n-acetylmorpholine and a number of higher N-acylmorpholines.Smooth and rapid substitution occurs in many cases, and good to excellent yields were obtained of arylacetic esters or acids, arylacetamides and arylalkanamides.The broad scope and limitations of the process have been defined, and the possible role of the ferrous ion is discussed.

Photostimulated Reactions of N,N-Disubstituted Amide Enolate Anions with Haloarenes by the SRN1 Mechanism in Liquid Ammonia

The photostimulated reactions of chloro-, bromo-, and iodobenzenes, 1-chloronaphthalene, and 9-bromophenanthrene with the enolate anion of N-methyl-N-phenylacetamide in liquid ammonia gave good yields of substituted products.In the dark, iodobenzene gave 34percent of substitution product, but chlorobenzene did not react.The enolate anion of N,N-dimethylacetamide was only partially soluble in liquid ammonia, but good yields of substitution products were obtained.The enolate anion of N-acetylpiperidine was insoluble in liquid ammonia, but the enolate anion of N-acetylmorpholine was soluble and good yields of substitution products were obtained under photostimulation.It is suggested that these reactions occur by the SRN1 mechanism of aromatic substitution.