1413931-29-9Relevant articles and documents
Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors
Guo, Zizhao,Zhuang, Chunlin,Zhu, Lingjian,Zhang, Yongqiang,Yao, Jianzhong,Dong, Guoqiang,Wang, Shengzheng,Liu, Yang,Chen, Hai,Sheng, Chunquan,Miao, Zhenyuan,Zhang, Wannian
, p. 10 - 16,7 (2012/12/11)
In order to discuss the structure-activity relationship (SAR) of the thio-benzodiazepine compounds which showed excellent activity against p53-MDM2 protein-protein interaction, we designed and synthesized twenty compounds with electrophilic and nucleophil