141421-46-7

Basic information

• Product Name: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-hydroxy-2-[4-(1-methylethyl)phenyl]-
• CAS NO: 141421-46-7
• Molecular Formula: C14H13N3O2S
• Molecular Weight: 287.342
• Mol File: 141421-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-hydroxy-2-[4-(1-methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-hydroxy-2-[4-(1-methylethyl)phenyl]-(141421-46-7)
• EPA Substance Registry System: 5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 7-hydroxy-2-[4-(1-methylethyl)phenyl]-(141421-46-7)

Safety Data

• Hazardous Substances Data: 141421-46-7(Hazardous Substances Data)

Upstream product

• 13816-33-6 p-Cyanocumen 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 
• 100987-89-1 5-[4-(Propan-2yl)phenyl]-1,3,4-thiadiazol-2-amine 

Downstream Products

• 141422-10-8 7-Amino-2-(4-isopropyl-phenyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 141421-90-1 7-Chloro-2-(4-isopropyl-phenyl)-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 101302-35-6 6-(4-Isopropyl-phenyl)-3H-[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9-one 
• 101367-13-9 6,7-Diamino-2-(4-isopropyl-phenyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 

Relevant articles and documents

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. I

A series of 6-substituted [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives 4a-z were synthesized from 5-substituted-1,3,4-thiadiazol-2-amines 5 by the following consecutive reactions: pyrimidine ring closure with bis(2,4,6-trichlorophenyl) malonate, nitration, chlorination, amination, hydrogenation and diazotization. The structure of 4 was confirmed by an alternate synthesis of 4, involving reaction of 5-substituted 2-azido-1,3,4-thiadiazole 13 with ethyl cyanoacetate, followed by the Dimroth rearrangement and ring closure. The antiallergic activities (anti-passive peritoneal anaphylaxis, anti-passive cutaneous anaphylaxis and anti-slow reacting substance of anaphylaxis activities) of the products were evaluated.