1414261-77-0

Usage

Classification

brominated organic compound

Molecular structure

a benzene ring with a bromine atom at the 1-position and a p-tolylethyl group at the 4-position

Usage

commonly used in organic synthesis and chemical research as a reagent for various reactions

Applications

potential applications in pharmaceuticals, agrochemicals, and material science

Reactivity

versatile reactivity and functional group compatibility

Hazardous nature

considered hazardous and may pose health and environmental risks if not properly managed

Handling

should be handled with caution and proper safety measures should be taken to minimize risks

Upstream product

• 617-86-7 triethylsilane 
• 99-90-1 para-bromoacetophenone 
• 108-88-3 toluene 
• 5720-05-8 4-methylphenylboronic acid 
• 75230-51-2 4-bromoacetophenone tosylhydrazone 
• 66117-64-4 di(p-tolyl)borinic acid 

Relevant academic research and scientific papers

Multi-component one-pot reaction of aromatic carbonyl compounds, tosylhydrazide, and arylboronic acids

In this paper, we developed a new method using 4-bromoacetophenone as the starting material, with tosylhydrazide and two arylboronic acids using Barluenga and Suzuki couplings in a four-component one-pot reaction to afford the target product 4-benzyl-1,1-biphenyls. This system that we have developed enables the use of easily accessible starting materials and can be employed on a wide variety of substrates with good functional group tolerance. In particular, this protocol can be applied to the synthesis of 4-(1-([1,1-biphenyl]-4-yl)ethyl)pyridine derivatives, a class of potential analogs of CPY17 inhibitors of prostate cancer.

Synthesis of diarylmethanes via metal-free reductive cross-coupling of diarylborinic acids with tosyl hydrazones

This paper describes a practical and efficient procedure that takes advantage of diarylborinic acids as a cost-effective alternative to arylboronic acids for synthesis of diarylmethanes through metal-free reductive cross-coupling with N-tosylhydrazones of aromatic aldehydes and ketones. The procedure tolerates hydroxyl, halide, amine, and allyl functionality, complementary to the transition-metal catalyzed cross-coupling techniques.

Influence of lewis acid and solvent in the hydrosiylation of aldehydes and ketones with Et3SiH; Tris(pentafluorophenyl)borane B(C 6F5)3 versus Metal inflates [M(OTf) 3; M = Sc, Bi, Ga, and Al] - Mecha

The scope of the B(C6F5)3-catalyzed hydrosilylation of (X)Ph- CH=O and (X)Ph-C(R)=O was expanded to include a large set of subslitulents (X =H, p-Me, o-Me, p-F, o-F, p-Cl, p-Br, p-NO2m, m-NO2, p-Et; R