1414335-89-9Relevant academic research and scientific papers
Reconciling the stereochemical course of nucleopalladation with the development of enantioselective wacker-type cyclizations
Weinstein, Adam B.,Stahl, Shannon S.
, p. 11505 - 11509 (2013/01/15)
A stereochemical substrate probe was used to assess the factors that affect the stereochemical course of nucleopalladation in the context of an enantioselective Wacker-type reaction. The enantioselectivity correlates directly with the nucleopalladation pathway, and both the neutral-donor and anionic ligands on palladium are capable of controlling selectivity for cis- or trans-nucleopalladation (see scheme; TFA=trifluoroacetate). Copyright
Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines
Xu, Hai-Chao,Moeller, Kevin D.
supporting information; experimental part, p. 2839 - 2844 (2010/06/11)
Anodic olefin coupling reactions using a tosylamine trapping group have been studied. The cyclizations are favored by the use of a less-polar radical cation and more basic reaction conditions. The most significant factor for obtaining good yields of cyclic product is the use of the more basic reaction conditions. However, a number of factors including the nature of both the solvent and the electrolyte used can influence the yield of the cyclizations. The cyclizations allow for the rapid synthesis of both substituted proline and pipecolic acid type derivatives.
