1414886-77-3

Basic information

• Product Name: 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one
• Synonyms: 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one
• CAS NO: 1414886-77-3
• Molecular Weight: 516.989
• Mol File: 1414886-77-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one(1414886-77-3)
• EPA Substance Registry System: 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one(1414886-77-3)

Safety Data

• Hazardous Substances Data: 1414886-77-3(Hazardous Substances Data)

Upstream product

• 109943-29-5 4-{1-[2-(p-tolyl)hydrazono]ethyl}pyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 539-44-6 N-4-methylphenylhydrazine 
• 1152876-95-3 3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazole-4-carbaldehyde 
• 63002-70-0 2-(4-chlorophenyl)-3-aminoquinazolin-4(3H)-one 

Relevant articles and documents

Synthesis and antitubercular activity of novel pyrazole-quinazolinone hybrid analogs

A series of 2-(substituted-phenyl)-3-(((3-(pyridin-4-yl)-1-(p-tolyl)-1H- pyrazol-4-yl)methylene)amino)-quinazolin-4(3H)-ones have been synthesized. The structures of the synthesized compounds were assigned on the basis of IR, 1H NMR, 13C NMR, and mass spectral data, while their abilities to inhibit growth of Mycobacterium tuberculosis in vitro have been determined. The results show that compounds 5a, 5c, 5d, 5g, and 5k exhibited excellent antitubercular activity with percentage inhibition of 96, 90, 94, 93, and 92, respectively at a minimum inhibitory concentration (MIC) of a MIC of >6.25 μg/mL. From the secondary screening, the actual MIC of compounds 5a, 5c, 5d, 5g, and 5k are 3.125.