1414889-30-7

Basic information

• Product Name: C₁₈H₁₂F₆N₂O₂
• Synonyms: C₁₈H₁₂F₆N₂O₂
• CAS NO: 1414889-30-7
• Molecular Weight: 402.296
• Mol File: 1414889-30-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₂F₆N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₂F₆N₂O₂(1414889-30-7)
• EPA Substance Registry System: C₁₈H₁₂F₆N₂O₂(1414889-30-7)

Safety Data

• Hazardous Substances Data: 1414889-30-7(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 489429-73-4 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone 
• 1233967-39-9 C₁₄H₁₃F₆NO₂ 
• 25617-34-9 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide 

Downstream Products

• 1414889-17-0 (S)-1-(4-methoxybenzyl)-2-oxo-4,6-bis(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile 
• 1414889-16-9 (R)-1-(4-methoxybenzyl)-2-oxo-4,6-bis(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-4-carbonitrile 
• 1593480-27-3 ethyl 2-(1-(4-methoxybenzyl)-2-oxo-4,6-bis(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)buta-2,3-dienoate 
• 1593480-13-7 (E)-ethyl 2-(5-(4-methoxybenzyl)-4-oxo-8,9b-bis(trifluoromethyl)-4,5-dihydro-1H-azeto[1,2-c]quinazolin-2(9bH)-ylidene)acetate 
• 1577989-41-3 (R)-phenyl-2-(1-(4-methoxybenzyl)-2-oxo-4,6-bis(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)acetate 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Arylation of Trifluoromethylated/Perfluoroalkylated 2-Quinazolinones with High Enantioselectivity

Asymmetric arylation of 4-fluoroalkyl-2-quinazolinone derivatives with arylboronic acids proceeded smoothly in the presence of a cationic palladium catalyst (1 mol %) coordinated with a chiral phosphinooxazoline (phox) ligand to create the corresponding fluorine-containing arylated dihydroquinazolinones in high yields and with greater than 99 % ee.

Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F3C-containing polycyclic dihydroquinazolinones

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethylN-acyl ketimines. Using aCinchonaalkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20?:?1 dr, up to 99% ee).