1414975-67-9Relevant academic research and scientific papers
Iron-catalyzed C-O bond functionalization of butyrolactam derivatives with various N-/C-nucleophiles
Ge, Danhua,Wang, Mao-Lin,Wang, Xin,Chu, Xue-Qiang
supporting information, p. 21064 - 21069 (2020/12/31)
An efficient iron-catalyzed C-O bond functionalization of butyrolactam derivatives with various N-/C-nucleophiles to enable the synthesis of pharmaceutically important butyrolactam derivatives has been developed here. The versatility of the present methodology is demonstrated for direct amination and carbonation by using a variety of sulfonamides, amines, amides, indoles, and 1,3-dicarbonyl compounds under mild conditions. The reaction also showed a wide substrate scope and synthetic simplicity. Additionally, only alcohol was produced as the by-product in all cases. This journal is
