1415034-35-3Relevant academic research and scientific papers
Tricyclic pyrazoles: An efficient approach to cannabinoid analogues with a tricyclic framework incorporating the pyrrole and pyrazole moieties
Pinna, Giansalvo,Pinna, Gerard A.,Chelucci, Giorgio,Baldino, Salvatore
, p. 2798 - 2804 (2012/11/07)
In this paper we report the synthesis of some new cannabinoid analogues that share with rimonabant, a potent and selective CB1 antagonist, the 2,4-dichlorophenyl and piperidin-1-yl substituents on the pyrazole and amide nitrogens, respectively. The general synthesis involves the preparation of a cyclic ketone condensed with a pyrrole, followed by Claisen condensation with diethyl oxalate; from here, an aza-annulation reaction with a substituted hydrazine followed by an amidation step complete the synthesis. Georg Thieme Verlag Stuttgart.New York.
