1415047-63-0Relevant academic research and scientific papers
Synthesis of new highly functionalized 1h-indole-2-carbonitriles via cross-coupling reactions
Hrizi, Asma,Cailler, Manon,Romdhani-Younes, Moufida,Carcenac, Yvan,Thibonnet, Jér?me
, (2021/09/06)
An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri-and tetra-substituted indole-2-carbonitriles.
Palladium-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines
Zeidan, Nicolas,Bognar, Sabine,Lee, Sophia,Lautens, Mark
, p. 5058 - 5061 (2017/11/07)
An efficient Pd(0)-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines is reported. Few methods have aimed to synthesize these scaffolds which are found in many natural products and have high bioactivity. This protocol features a robust c
