141523-16-2

Upstream product

• 71144-36-0 2-fluoro-4,5-dihydroxy-benzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 79418-72-7 4-Benzyloxy-2-fluoro-5-methoxybenzaldehyde 
• 79418-77-2 6-fluorovanillin 
• 141523-21-9 4-Benzyloxy-2-fluoro-5-methoxyphenethanolamine 
• 141523-18-4 2-Benzoylamino-3-(4-benzyloxy-2-fluoro-5-methoxyphenyl)acrylic acid 
• 141523-17-3 2-Benzoylamino-3-(4-benzyloxy-2-fluoro-5-methoxyphenyl)acrylic acid azlactone 
• 141523-20-8 (4-Benzyloxy-2-fluoro-5-methoxy-phenyl)-trimethylsilanyloxy-acetonitrile 
• 141523-19-5 N-Benzoyl-3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine 
• 141523-22-0 Ethyl 2-(4-benzyloxy-2-fluoro-5-methoxyphenyl)-2-hydroxyacetate 
• 141523-24-2 4-Benzyloxy-2-fluoro-5-methoxymandelic acid 
• 141523-23-1 4-Benzyloxy-2-fluoro-5-methoxyphenyl glycol 
• 141554-67-8 3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine 
• 141523-15-1 2-(2-fluoro-4-hydroxy-5-methoxyphenyl)-2-hydroxyacetic acid 
• 140146-47-0 2-(2-fluoro-4-hydroxy-5-methoxyphenyl)acetic acid 
• 141523-14-0 2-Fluoro-4-hydroxy-5-methoxyphenyl glycol 

Relevant academic research and scientific papers

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Synthesis of metabolites of 6-fluoro-DOPA

Key metabolites of 6-fluoro-DOPA have been prepared by side-chain elaboration of 6-fluorovanillin and 6-fluoroveratraldehyde.