140146-47-0Relevant academic research and scientific papers
Phenyl-fluoride substituted phenylacetic acid ester compound and use thereof
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, (2017/11/17)
The invention relates to a phenyl-fluoride substituted phenylacetate compound shown as a general formula (I), a pharmaceutical composition containing the same and application thereof to anesthesia, sedation and analgesia.
Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression
Zhang, Heng,Xu, Xiangqing,Chen, Yin,Qiu, Yinli,Liu, Xin,Liu, Bi-Feng,Zhang, Guisen
, p. 524 - 539 (2014/12/11)
We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.
SYNTHESIS AND HPLC SEPARATION OF 6-FLUORO-L-DOPA METABOLITES
Luxen, A.,Monclus, M.,Hendrickx, P.-Y.,Masson, C.,Melega, W. P.
, p. 217 - 226 (2007/10/02)
The synthesis of 6-fluoro-L-dopa metabolites (3-O-methyl-6-fluorodopa (1b), 6-fluorodopamine (2a), 3-O-methyl-6-fluorodopamine (2b), 3,4-dihydroxy-6-fluorophenylacetic acid (3a) and 6-fluorohomovanillic acid (3b) is described.A HPLC method for their separ
Synthesis of metabolites of 6-fluoro-DOPA
Nie, Jun-ying,Kirk, Kenneth L.
, p. 259 - 269 (2007/10/02)
Key metabolites of 6-fluoro-DOPA have been prepared by side-chain elaboration of 6-fluorovanillin and 6-fluoroveratraldehyde.
