1415263-09-0Relevant articles and documents
Stabilization of near identical hydrogen bonded octameric water clusters in crystal structures of three distinct non-charged polyamide macrocyclic host molecules
Ceborska, Magdalena,D?browa, Kajetan,Jurczak, Janusz
, (2021)
In this paper, we present a comparative analysis of the solid state structures of three wellresolved hydrates of macrocyclic host molecules 1a, 1b, and 2 containing an intrannular amide-aryl substituent (lariat arm) connected to a fixed 26-membered ring in a normal (-NHCOAr, hosts 1a and 1b) or reverse manner (-CONHAr, host 2). Despite different chemical structures, these hosts crystallize as isostructural tetrahydrates in the same P-1 space group. Moreover, their crystals exhibit identical hydrogen bond motifs resulting in a stabilization of an almost identical unusual octameric water cluster built from the cyclic tetramer core and four water molecules, attached sequentially in an “up-and-down” manner. Further analysis reveals that, among the series, the structure of host 2 provides the most suitable environment for the accommodation of this type of water cluster.
A General Method for Synthesis of Unclosed Cryptands via H-Bond Templated Macrocyclization and Subsequent Mild Postfunctionalization
Dabrowa, Kajetan,Niedbala, Patryk,Majdecki, MacIej,Duszewski, Piotr,Jurczak, Janusz
, p. 4774 - 4777 (2015)
A practical four-step synthesis of a model 26-membered N-Boc-protected macrocycle, starting from commercially available and inexpensive materials, is reported. The crucial macrocyclization step does not require high-dilution conditions and is completed in
"Unclosed cryptands": A point of departure for developing potent neutral anion receptors
Daì?browa, Kajetan,Pawlak, Marcin,Duszewski, Piotr,Jurczak, Janusz
, p. 6298 - 6301 (2013/02/25)
Six macrocyclic lariat-type compounds, representing a new class of anion receptors, were synthesized in a simple approach. We identified the optimal macroring size and the position of the hydrogen bond donating center in the lariat arm offering the best a