14153-75-4Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 3-(4-halophenyl)-3- oxopropanal and their derivatives as novel antibacterial agents
Liu, Jinbing,Yi, Wei,Hu, Jianming,Wu, Fengyan,Zhao, Liangzhong,Song, Huacan,Wang, Zhihou
experimental part, p. 1127 - 1131 (2010/11/05)
In continuing our program aimed to search for potent drugs for bacterial infections, a series of 3-(4-halophenyl)-3-oxopropanal and their derivatives were designed, synthesized and their antibacterial activities in vitro against both Gram-positive bacteri
Identification and optimisation of 5-amino-7-aryldihydro-1,4-diazepines as 5-HT2A ligands
Swain, Christopher J.,Teran, Ana,Maroto, Marta,Cabello, Angeles
, p. 6058 - 6062 (2007/10/03)
A several series of low molecular weight 5-HT2A leads were identified from an analysis of HTS data, the exploration of SAR and optimization of one series using parallel synthesis are described, affording compound 22 (5-HT2A IC50 1.1 nM).
