1415343-88-2

Basic information

• Product Name: 4,(1S,3R,4R,5R)-4-acetyloxy-5-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3-dihydroxycyclohexanecarboxylic acid
• Synonyms: 4,(1S,3R,4R,5R)-4-acetyloxy-5-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3-dihydroxycyclohexanecarboxylic acid
• CAS NO: 1415343-88-2
• Molecular Weight: 396.351
• Mol File: 1415343-88-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4,(1S,3R,4R,5R)-4-acetyloxy-5-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3-dihydroxycyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,(1S,3R,4R,5R)-4-acetyloxy-5-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3-dihydroxycyclohexanecarboxylic acid(1415343-88-2)
• EPA Substance Registry System: 4,(1S,3R,4R,5R)-4-acetyloxy-5-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3-dihydroxycyclohexanecarboxylic acid(1415343-88-2)

Safety Data

• Hazardous Substances Data: 1415343-88-2(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 202650-88-2 3-caffeoylquinic acid 
• 64-19-7 acetic acid 

Relevant articles and documents

Antioxidant activities of chlorogenic acid derivatives with different acyl donor chain lengths and their stabilities during in vitro simulated gastrointestinal digestion

In this study, chlorogenic acid (CA) was acylated with vinyl esters of different carbon chain lengths under the action of the lipase Lipozyme RM. Five CA derivatives (C2-CA, C4-CA, C6-CA, C8-CA, and C12-CA) with different lipophilicities were obtained, and their digestive stabilities and antioxidant activities were evaluated. The lipophilicities were positively correlated with the digestive stabilities of CA derivatives. The antioxidant activities of CA derivatives did not change with the reduction of phenolic hydroxyl groups, and their capacity to scavenge 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+?) and 1,1-diphenyl-2-picrylhydrazyl (DPPH?) were similar to those of CA. In cellular antioxidant activity (CAA) tests, it was found that the capacity of these derivates to cross cell membranes were enhanced upon enhancing lipophilicity, and their antioxidant activities were improved. C12-CA showed the best antioxidant activity with a median effective dose (EC50) of 9.40 μg/mL, which was significantly lower than that of CA (i.e., 29.08 μg/mL).

Formation of ester and amine derivatives of 5-O-caffeoylquinic acid in the process of its simulated extraction

Chlorogenic acid (CQA), the ester of caffeic acid with quinic acid, supplied to human organisms mainly through coffee, tea, fruits, and vegetables, is one of the most studied polyphenols. It is potentially useful in pharmaceuticals, foodstuffs, feed additives, and cosmetics due to its recently discovered biomedical activity. This finding caused new interest in its properties, its isomers, and its natural occurrence. The presented study shows that 5-O-caffeoylquinic acid, during its buffered water extraction, not only undergoes such transformation as isomerization, water molecule addition, and hydrolysis but also reacts with buffer components forming its derivatives. The amount of each formed component depends on the heating time, buffer pH, and buffer type. Although the concentrations of these components are low, they can be mistakenly treated as a new component not previously found in the examined plant or can be a cause of erroneous quantitative estimations of plant composition.