141544-18-5

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 72563-39-4 diethyl <(N-methylcarbamoyl)methyl>phosphonate 
• 60-29-7 diethyl ether 
• 10026-13-8 phosphorus pentachloride 
• 21613-47-8 4t-(4-methoxy-phenyl)-but-3-en-2-one-seqcis-oxime 
• 141544-12-9 2-(4-Methoxy-phenyl)-4-methyl-6-oxo-cyclohex-4-ene-1,3-dicarboxylic acid bis-methylamide 
• 132599-16-7 4-hydroxy-2-(4-methoxyphenyl)-N,N',4-trimethyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxamide 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Mild zinc-promoted Horner-Wadsworth-Emmons reactions of diprotic phosphonate reagents

We report the development of a mild protocol for the Horner-Wadsworth- Emmons reaction of diprotic phosphonates that makes use of a zinc triflate promoter in the presence of mild ter-tiary amine bases to produce α,β-unsaturated carboxylic acids and amides. Georg Thieme Verlag Stuttgart.

Synthesis and reactions of 2-substituted ethyl N-alkylmalonylhydroxamic acids

Alkylation of O-silylated N-alkylmalonylhydroxamic acids provides a method for the synthesis of 2-substituted N-alkylmalonyl hydroxamic acids. The substituent at C-2 does not materially change the chemistry of the α-lactam intermediates produced from them. They can be converted to unsymmetric ureas and hydantoins in high yields. The addition of unsaturated substituents at C-2 is used to produce cyclic ureas containing medium rings via RCM reactions.

An Unusual Ring-Cleavage of 2,4-Di-N-methylcarbamoylcyclohexanones into Glutaconimide and Cinnamamides

3-Aryl-5-hydroxy-5-methyl-2,4-di-N-methylcarbamoylcyclohexanones (1a-h) under acidic and basic conditions underwent ring-cleavage to give 1,4-dimethylglutaconimide (3) and substituted N-methylcinnamamides (4a-h).The probable mechanism for the formation of