1415481-75-2

Basic information

• Product Name: 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid
• Synonyms: 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid
• CAS NO: 1415481-75-2
• Molecular Weight: 489.86
• Mol File: 1415481-75-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid(1415481-75-2)
• EPA Substance Registry System: 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid(1415481-75-2)

Safety Data

• Hazardous Substances Data: 1415481-75-2(Hazardous Substances Data)

Upstream product

• 956229-69-9 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid tert-butyl ester 
• 1244642-70-3 methyl 3-bromo-4,5-difluorobenzoate 
• 1415312-30-9 (2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester 
• 1415481-76-3 5',6'-difluoro-biphenyl-2,3'-dicarboxylic acid 2-t-butyl ester 
• 80126-50-7 (R)-2'-chlorophenylalanine 
• 1415312-26-3 [(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester 
• 1270301-63-7 C₁₇H₁₆ClNO₄ 
• 1415312-22-9 C₁₉H₂₁ClN₂O₄ 
• 1415312-24-1 C₁₇H₁₆ClNO₃ 

Relevant articles and documents

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, a, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.