141554-38-3

Upstream product

• 87678-65-7 (S)-(-)-2-benzyloxyhexanal 
• 110352-59-5 methyl (S)-2-benzyloxyhexanoate 
• 70267-26-4 (S)-2-hydroxyhexanoic acid 
• 327-57-1 L-Norleucine 
• 106225-85-8 methyl (S)-(+)-2-hydroxyhexanoate 
• 100-39-0 benzyl bromide 
• 87604-60-2 (S)-(+)-2-benzyloxyhexan-1-ol 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

High Diastereoselection in the Aldol Reaction of the Bistrimethylsilyl Enol Ether of Methyl Acetoacetate with 2-Benzyloxyhexanal: Synthesis of (-)-Pestalotin

Aldol condensation of the bistrimethylsilyl enol ether of methyl acetoacetate, compound 2, with 2-benzyloxyhexanal 3c affords highly selectively (99:1) the syn-aldol adduct 4c in the presence of titanium tetrachloride.The stereocontrolled synthesis of (-)-pestalotin 7 has been achieved.

Highly Diastereoselective Titanium Tetrachloride-mediated Aldol Condensation of the Bistrimethylsilyl Enol Ether of Acetoacetic Ester with 2-Benzyloxyhexanal. A Synthesis of (-)-Pestalotin

Titanium tetrachloride-mediated aldol condensation of the bistrimethylsilyl enol ether of methyl acetoacetate (1) with 2-benzyloxyhexanal (3) gives highly selectively (99:1) the syn aldol adduct (5); the stereocontrolled synthesis of (-)-pestalotin (9) ha