1415580-95-8Relevant articles and documents
Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with click chemistry
Li, Xianlin,Tu, Zhenchao,Li, Hua,Liu, Chunping,Li, Zheng,Sun, Qiao,Yao, Yiwu,Liu, Jinsong,Jiang, Sheng
, p. 132 - 136 (2013/03/13)
We report the design, synthesis, and biological evaluation of a new series of largazole analogues in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, respectively. Compound 7 bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole molecular scaffold.