1415591-26-2Relevant academic research and scientific papers
Discovery of a novel series of 4-quinolone JNK inhibitors
Gong, Leyi,Tan, Yun-Chou,Boice, Genevieve,Abbot, Sarah,McCaleb, Kristen,Iyer, Pravin,Zuo, Fengrong,Porto, Joseph Dal,Wong, Brian,Jin, Sue,Chang, Alice,Tran, Patricia,Hsieh, Gary,Niu, Linghao,Shao, Ada,Reuter, Deborah,Lukacs, Christine M.,Ursula Kammlott,Kuglstatter, Andreas,Goldstein, David
, p. 7381 - 7387 (2013/02/21)
A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well as improvements in the physicochemical properties of the series. Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.
