1080673-69-3

Upstream product

• 5781-53-3 monomethyl oxalyl chloride 
• 1415591-26-2 C₂₂H₂₂N₂O₃S 
• 30529-70-5 2-chloro-6-methyl nicotinic acid 
• 1057667-23-8 2-chloro-N-methoxy-N,6-dimethylpyridine-3-carboxyamide 
• 49667-29-0 1-(2-chloro-6-methyl-pyridin-3-yl)-ethanone 
• 1080675-02-0 1-(6-methyl-2-phenylamino-pyridin-3-yl)-ethanone 
• 1421757-18-7 C₂₂H₂₀N₂O₃S 

Relevant academic research and scientific papers

Discovery of a novel series of 4-quinolone JNK inhibitors

A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well as improvements in the physicochemical properties of the series. Compound (13c) has an IC50 of 62/170 nM for JNK1/2, excellent kinase selectivity and impressive efficacy in a rodent asthma model.

Dihydroquinone and dihydronaphthridine inhibitors of JNK

Compounds of formula I are effective modulators of JNK: wherein X is CR11 or N;Y is —C(O)R3, 5-membered heteroaryl, or 5-membered heterocyclyl;Z is phenyl, cycloalkyl, heterocyclyl or heteroaryl, and is substituted with R1 and R2;R1 and R2 are each independently H, halo, CN, lower alkyl, or —Y1—Y2—Y3—R8, or R1 and R2 together form —O(CH2)nO—, where n is 1 or 2; Y1 is —O—, —C(O)—, —C(O)O—, —C(O)NR9—, —NR9C(O)—, —S—, —SO2—, or a bond;Y2 is cycloalkylene, heterocycloalkylene, lower alkylene or a bond;Y3 is —O—, —C(O)—, —C(O)O—, —C(O)NR9—, —NR9C(O)—, —SO2—, or a bond;R8 is H, lower alkyl, lower alkoxy, cycloalkyl, heterocycloalkyl, or —NR9R10, wherein R8 other than H is optionally substituted with lower alkyl, halo, —CF3, or —OH; R9 and R10 are each independently H or lower alkyl;R3 is OH, lower alkyl, lower alkoxy, (lower alkoxy)-lower alkoxy, or —NR9R10;R4 is lower alkyl, phenyl, heterocyclyl, cycloalkyl, heterocycloalkyl, or heteroaryl, and is optionally substituted with lower alkyl, hydroxy, lower alkoxy, halo, nitro, amino, cyano, or halo-lower alkyl;R5 and R6 are each independently H, halo, cyano, lower alkyl, —CF3, lower alkoxy, —OCHF2, —NO2, or —NR9R10;R7 is H, F, Cl, methyl, or OH;R11 is H, lower alkyl, lower cycloalkyl, or phenyl;or a pharmaceutically acceptable salt thereof.