1415609-45-8

Basic information

• Product Name: 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one
• Synonyms: 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one
• CAS NO: 1415609-45-8
• Molecular Weight: 363.821
• Mol File: 1415609-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one(1415609-45-8)
• EPA Substance Registry System: 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one(1415609-45-8)

Safety Data

• Hazardous Substances Data: 1415609-45-8(Hazardous Substances Data)

Upstream product

• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 17630-75-0 5-chloro-indolin-2-one 
• 1415609-52-7 3-methoxy-4-(methylsulfonyl)benzaldehyde 

Relevant articles and documents

Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3

The inhibition of FLT-3 activity is an interesting target for the treatment of acute myeloid leukemia (AML). The serendipitous identification of FLT-3 inhibitors from a CK1/γ-secretase programme provided compounds with dual inhibitory activity. We analyzed the structure-activity relationship of these inhibitors and derivatized them to arrive at compounds with reduced impact on γ-secretase activity and enhanced FLT-3 inhibition.