14160-00-0

Upstream product

• 55-21-0 benzamide 
• 57152-27-9 N-[(methylthio)methyl]benzamide 
• 81-07-2 saccharin 
• 182925-82-2 N-(saccharinyl)-acetic acid azide 
• 128-44-9 saccharin sodium salt 
• 52188-11-1 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid 
• 182925-83-3 N-(saccharinyl)-acetyl isocyanate 
• 71-43-2 benzene 
• 13947-20-1 N-(hydroxymethyl)saccharin 
• 100-47-0 benzonitrile 
• 61020-33-5 2-[1,1-dioxide-3-oxo-1,2-benzisothiazole-2(3H)-yl] acetic acid chloride 

Relevant academic research and scientific papers

DMSO-Mediated Synthesis of Methylene-Bridged Unsymmetrical Bisamides in the Presence of AcOH

A simple and efficient procedure for the synthesis of N -[(methylthio)methyl]benzamides and methylene-bridged unsymmetrical bisamides was achieved mediated by DMSO in the presence of acetic acid. DMSO plays a dual role in the transformation, as not only a solvent, but also an environmentally benign methylene source. The protocol provides new strategies for effective synthesis of unsymmetrical bisamides and avoids the use of transition-metal catalysts.

Synthesis of some saccharin derivatives of expected biological activity based on n-(saccharinyl)-acetic acidazide

Azide 3 was prepared from the corresponding acid chloride 2. The base catalyzed decomposition with aromatic amines, aminobenzoic acids and/or hydrazines afforded the corresponding anilides 4a-f and/or hydrazides 5a-d via azido group displacement. Compounds 5c and 5d were refluxed in Ac2O to give 1,3,4-oxadiazole derivatives 6a and 6b. Lewis acid catalyzed decomposition of azide 3 with anhyd. AlCl3 in dry aromatic substrates gave the corresponding ketones 7a-c. Also, the reaction of azide 3 with glycine gave 9.