1416548-73-6

Basic information

• Product Name: 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide
• Synonyms: 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide
• CAS NO: 1416548-73-6
• Molecular Weight: 383.488
• Mol File: 1416548-73-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide(1416548-73-6)
• EPA Substance Registry System: 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide(1416548-73-6)

Safety Data

• Hazardous Substances Data: 1416548-73-6(Hazardous Substances Data)

Upstream product

• 73441-42-6 methyl 5-chloro-2,2-dimethylpentanoate 
• 95-87-4 2,5-Dimethylphenol 
• 25812-30-0 gemfibrozil 
• 19745-72-3 ω-amino-4-hydroxyacetophenone hydrochloride 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 17194-82-0 2-(4-hydroxyphenyl)acetamide 
• 77369-38-1 2-amino-1-(4-hydroxyphenyl)ethyl ketone 
• 99-93-4 4-Hydroxyacetophenone 
• 41104-10-3 acetic acid 4-(2-bromoacetyl)phenyl ester 

Relevant articles and documents

Synthesis method for SIPI7623 metabolite of FXR antagonist

The invention provides a synthesis method for an SIPI7623 metabolite, belonging to the field of drug synthesis. The synthesis method has the advantages of reasonable process design, simple operation method and high purity of a prepared target product. The synthesis method comprises the following steps: taking 2,5-dimethylphenol as an initial raw material, then carrying out a nucleophilic substitution reaction, a hydrolysis reaction, an amide condensation reaction and glycosyl modification, and carrying out a hydrolysis reaction so as to obtain a target molecule. The synthesis method provided by the invention is reasonable in route design; and a target product prepared by using the synthesis method provided by the invention provides a test sample for research of the metabolic mechanism of SIPI7623 and has an important value in clinical pharmacokinetic research.

An amide compound, wherein the intermediate and the process for the preparation of intermediate

The invention discloses preparation methods of amide-type compound 1 and intermediate 8 and the intermediate 8. The preparation method of the compound 1 comprises: in the solvent with alkali, the compound 8 is hydrolyzed, and the compound 1 is obtained; w

AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.