1416892-87-9Relevant academic research and scientific papers
Novel synthetic route to α-aminophosphonates containing benzothiazole moiety
Gu, Liju,Wang, Rui,Huang, Xiangzhong,Jin, Cheng
, p. 2483 - 2487,5 (2020/09/16)
A novel and ef?cient synthetic route to α-aminophosphonates containing benzothiazole moiety via a cascade three-component reaction from conveniently available starting materials has been developed. The target compounds 3a-3g, 7 and 8a, 8b were evaluated for their anticancer activities against the cancer cell line HL-60 in vitro by the MTT method. Compound 3g showed good cancer inhibitory activity against the tested cell line. Further study is necessary to find out the potential antitumor activities. A novel and ef?cient synthetic route to α-aminophosphonates containing benzothiazole moiety via a cascade three-component reaction from conveniently available starting materials has been developed. Copyright
