1416958-91-2

Upstream product

• 29906-47-6 1-benzyl-2-methylpiperazin-3-one 
• 64892-53-1 N-benzylalanine ethyl ester 
• 60930-36-1 ethyl (RS)-2-(benzylideneamino)propanoate 
• 98-88-4 benzoyl chloride 
• 13754-41-1 4-benzyl-piperazin-2-one 
• 1416958-90-1 allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate 

Relevant academic research and scientific papers

Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation

The asymmetric palladium-catalyzed decarboxylative allylic alkylation of differentially N-protected piperazin-2- ones allows the synthesis of a variety of highly enantioenriched tertiary piperazine-2-ones. Deprotection and reduction affords the corresponding tertiary piperazines, which can be employed for the synthesis of medicinally important analogues. The introduction of these chiral tertiary piperazines resulted in imatinib analogues which exhibited comparable antiproliferative activity to that of their corresponding imatinib counterparts.

QUATERNARY HETEROATOM CONTAINING COMPOUNDS

A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; Rl through R1 1 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R1 1, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.