141719-97-3

Upstream product

• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 6103-22-6 5-hydroxymethyl-5-methyl-2-phenyl[1,3]dioxane 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 327029-56-1 2-[(4,4’-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol 
• 123-76-2 levulinic acid 

Downstream Products

• 1151988-69-0 C₄₂H₄₆Cl₂FeNO₈P 
• 1151988-59-8 C₄₂H₄₇ClFeNO₈P 
• 1151988-50-9 C₄₂H₄₈FeNO₈P 
• 1151988-46-3 C₄₇H₅₈FeNO₈P 

Relevant academic research and scientific papers

Modified Galacto- or Fuco-Clusters Exploiting the Siderophore Pathway to Inhibit the LecA- or LecB-Associated Virulence of Pseudomonas aeruginosa

Galacto- and fuco-clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono- and tricatechol galactoclusters (G1C and G3C) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster (G0). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0. This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism.

Preparation method of compound

The invention discloses a preparation method of a compound. The compound has a structure shown in the formula I. The preparation method comprises that a compound II and a compound III undergo a reaction to produce a solution of an intermediate IV under action of an acid/azole complex, a compound V is added into the solution of the intermediate IV, the mixture undergoes a reaction to produce a solution of an intermediate VI under action of an acid/azole complex, a butanone peroxide solution is slowly added into the solution of the intermediate VI so that a solution of an intermediate VII is obtained, a hydrazine acetate solution is slowly added into the solution of the intermediate VII so that a compound VIII is obtained, and the compound VIII and the compound III undergo a reaction under action of an acid/azole complex to produce a compound I.

BASELESS NUCLEOTIDE ANALOGUES AND USES THEREOF

A method of detecting a target nucleic acid.