6103-22-6

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

The compound is in a liquid state and has no color.

Explanation

The compound has a mild, sweet smell.

Explanation

The compound is used in the manufacturing of pharmaceuticals and serves as a solvent in different industries.

Explanation

It is derived from dioxane, which is a cyclic ether.

Explanation

The compound has a phenyl group (C6H5) and a methyl group (CH3) as part of its structure.

Explanation

The compound poses health risks if it is swallowed, breathed in, or comes into contact with the skin.

Explanation

Exposure to the compound may result in eye and respiratory irritation.

Physical state

Colorless liquid

Odor

Slightly sweet

Applications

Production of pharmaceuticals and as a solvent in various industrial processes

Chemical classification

Derivative of dioxane

Structural features

Contains a phenyl and a methyl group

Safety precautions

Harmful if ingested, inhaled, or in contact with the skin

Potential hazards

Causes irritation to the eyes and respiratory tract

Upstream product

• 77-85-0 2-(hydroxymethyl)-2-methylpropane-1,3-diol 
• 100-52-7 benzaldehyde 
• 207850-04-2 5-methyl-2-phenyl-1,3-dioxane-5-carboxylic acid 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 74151-89-6 (5-bromomethyl-2-phenyl-[1,3]dioxan-5-yl)-methanol 
• 109-99-9 tetrahydrofuran 
• 5688-09-5 7-phenyl-2,6,8-trioxa-spiro[3.5]nonane 

Downstream Products

• 368886-40-2 tert-butyldimethyl-(5-methyl-2-phenyl-[1,3]dioxan-5-ylmethoxy)silane 
• 4270-73-9 2-methyl-2-<(benzyloxy)methyl>-1,3-propanediol 
• 141719-97-3 2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate 
• 1207867-28-4 C₁₅H₁₈O₄ 
• 1033037-71-6 C₁₁₀H₂₀₁N₉O₁₇ 
• 959420-95-2 (5-methyl-2-phenyl-1,3-dioxan-5-yl)methyl methacrylate 
• 1020110-26-2 5-(dodecyloxy)methyl-5-methyl-2-phenyl-1,3-dioxane 

Relevant academic research and scientific papers

Synthesis of the Hemoglobin-Conjugated Polymer Micelles by Thiol Michael Addition Reactions

Amphiphilic triblock copolymers mPEG-b-PMAC-b-PCL are synthesized using methoxyl poly(ethylene glycol), cyclic carbonic ester monomer including acryloyl group, and ε-caprolactone. Copolymers are self-assembled into core–shell micelles in aqueous solution. Thiolated hemoglobin (Hb) is conjugated with micelles sufficiently through thiol Michael addition reaction to form hemoglobin nanoparticles (HbNs) with 200 nm in diameter. The conjugation of Hb onto the micelle surface is further confirmed by X-ray photoelectron spectroscopy. Feeding ratio of copolymer micelles to Hb at 1:3 would lead to the highest hemoglobin loading efficiency 36.7 wt%. The UV results demonstrate that the gas transporting capacity of HbNs is well remained after Hb is conjugated with polymeric micelles. Furthermore, the obtained HbNs have no obvious detrimental effects on blood components in vitro. This system may thus have great potential as one of the candidates to be developed as oxygen carriers and provide a reference for the modification of protein drugs. (Figure presented.) .

Homopolymerization and copolymerization kinetics of trimethylene carbonate bearing a methoxyethoxy side group

The polymerization kinetics of 5-[2-{2-(2-methoxyethoxy)ethyoxy}-ethoxymethyl]-5-methyl-trimethylene carbonate (TMCM-MOE3OM) synthesized using the organocatalyst 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were studied and compared to those with the commonly used catalyst/initiator for ring-opening polymerization of cyclic carbonates and esters, stannous 2-ethylhexanoate. Further, the utility of each of these catalysts in the copolymerization of TMCM-MOE3OM with trimethylene carbonate (TMC) and l-lactide (LLA) was examined. Regardless of conditions with either catalyst, homopolymerization of TMCM-MOE3OM yielded oligomers, having number average molecular weight less than 4000 Da. The resultant molecular weight was limited by ring-chain equilibrium as well as through monomer autopolymerization. Interestingly, autopolymerization of TMC was also achieved with DBU as the catalyst. Copolymerization with TMC using stannous 2-ethylhexanoate as the catalyst yielded random copolymers, while diblock copolymers were formed by copolymerization with LLA. With DBU as the catalyst, copolymers with LLA could not be formed, while blocky copolymers were formed with TMC. These findings should be useful in the incorporation of this monomer in the design of polymer biomaterials.

An investigation of siloxane cross-linked hydroxyapatite-gelatin/copolymer composites for potential orthopedic applications

Causes of bone deficiency are numerous, but biomimetic alloplastic grafts provide an alternative to repair tissue naturally. Previously, a hydroxyapatite-gelatin modified siloxane (HAp-Gemosil) composite was prepared by cross-linking N,N'-bis[(3-trimethoxysilyl)propyl]ethylene diamine (enTMOS) around the HAp-gel nanocomposite particles, to mimic the natural composition and properties of bone. However, the tensile strength remained too low for many orthopedic applications. It was hypothesized that incorporating a polymer chain into the composite could help improve long range interaction. Furthermore, designing this polymer to interact with the enTMOS siloxane cross-linked matrix would provide improved adhesion between the polymer and the ceramic composite, and improve mechanical properties. To this end, copolymers of l-lactide (LLA), and a novel alkyne derivatized trimethylene carbonate, propargyl carbonate (PC), were synthesized. Incorporation of PC during copolymerization affects properties of copolymers such as molecular weight, Tg, and %PC incorporation. More importantly, PC monomers bear a synthetic handle, allowing copolymers to undergo post-polymerization functionalization with graft monomers to specifically tailor the properties of the final composite. For our investigation, P(LLA-co-PC) copolymers were functionalized by an azido-silane (AS) via copper catalyzed azide-alkyne cycloaddition (CuAAC) through terminal alkyne on PC monomers. The new functionalized polymer, P(LLA-co-PC)(AS) was blended with HAp-Gemosil, with the azido-silane linking the copolymer to the silsesquioxane matrix within the final composite. These HAp-Gemosil-P(LLA-co-PC) (AS) composites were subjected to mechanical and biological testing, and the results were compared with those from the HAp-Gemosil composites. This study revealed that incorporating a cross-linkable polymer served to increase the flexural strength of the composite by 50%, while maintaining the biocompatibility of HAp-Gemosil ceramics.

Selective monobenzylation of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) to yield an AB linear monomer and analogous linear oligomers

The synthesis of a mono-benzylated AB monomer based on bis-MPA is explored and accomplished via a three-step synthesis without column chromatography. This optimized synthesis utilizes a generic acid-catalyzed esterification of bis-MPA to the ethyl ester.

MANUFACTURING METHOD OF TRIMETHYLENE CARBONATE DERIVATIVE

PROBLEM TO BE SOLVED: To enable easily synthesizing a trimethylene carbonate derivative containing no ester bond. SOLUTION: The manufacturing method of a trimethylene carbonate derivative having a process for obtaining a compound A represented by the following formula (2) by protecting hydroxyl groups at 2 locations of trimethylolalkane represented by the following formula (1) by a protection agent at same time, a process for obtaining a compound B represented by the formula (3) and having 2 hydroxyl groups by reducing the compound A by a reductant and deprotecting only one of the 2 locations, a process for obtaining a trimethylene carbonate derivative represented by the formula (4) by carbonylating 2 hydroxyl groups of the compound B. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Polymeric depots for localization of agent to biological sites

Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.

Novel synthesis method of ester free trimethylene carbonate derivatives

Ester free poly(trimethylene carbonate) (PTMC) derivatives show biocompatibility and biodegradability and do not generate any acidic compounds after decomposition. Their syntheses methods are limited however, hampering their material application. Herein, we established a novel synthesis route of ester free trimethylene carbonate (TMC) derivatives. The novel synthesis route was described using six aldehydes and one ketone as starting compounds. The key reaction is the selective deprotection from two protected hydroxyl groups in the cyclic acetal structure by diisobutylaluminium hydride. This novel synthesis route means that it is possible to convert aldehyde group to ether groups in the side chain of TMC. Conventionally, only a substituent derived from a primary alcohol was introduced into the side chain. We therefore succeeded in decreasing the number of reaction steps from five to three, compared with the conventional route. Furthermore, the development of a novel synthesis route enabled the introduction of substituents derived from secondary alcohols, anticipating the creation of further types of ester free TMC derivatives.

Efficient synthesis of ether phosphonates using trichloroacetimidate and acetate coupling methods

A series of ether phosphonates have been prepared by trichloroacetimidate and acetate coupling methods. Trichloroacetimidates or acetates were treated with primary and secondary alcohols as O-nucleophiles in the presence of catalytic TMSOTf to afford 21 examples of diethyl alkyloxy(substitutedphenyl)methyl phosphonates via C-O bond formation in 55-90% yields and short reaction time.

Preparation method of compound

The invention discloses a preparation method of a compound. The compound has a structure shown in the formula I. The preparation method comprises that a compound II and a compound III undergo a reaction to produce a solution of an intermediate IV under action of an acid/azole complex, a compound V is added into the solution of the intermediate IV, the mixture undergoes a reaction to produce a solution of an intermediate VI under action of an acid/azole complex, a butanone peroxide solution is slowly added into the solution of the intermediate VI so that a solution of an intermediate VII is obtained, a hydrazine acetate solution is slowly added into the solution of the intermediate VII so that a compound VIII is obtained, and the compound VIII and the compound III undergo a reaction under action of an acid/azole complex to produce a compound I.

POLYMERIC DEPOTS FOR LOCALIZATION OF AN AGENT TO BIOLOGICAL SITES

no abstract published