141741-24-4Relevant academic research and scientific papers
Asymmetric synthesis of Sulindac esters by enantioselective sulfoxidation in the presence of chiral titanium complexes
Naso, Francesco,Cardellicchio, Cosimo,Affortunato, Francesco,Capozzi, Maria Annunziata M.
, p. 3226 - 3229 (2006)
High ee values (up to 94-96% ee) and moderate isolated yields (48-50%) were achieved in the preparation of Sulindac alkyl esters. These molecules are simple and straightforward precursors of Sulindac, an anti-inflammatory drug that has also been recently
Synthesis, pharmacological evaluation and docking studies of new sulindac analogues
Romeiro, Nelilma C.,Leite, Ramon D.F.,Lima, Lidia M.,Cardozo, Suzana V.S.,de Miranda, Ana L.P.,Fraga, Carlos A.M.,Barreiro, Eliezer J.
experimental part, p. 1959 - 1971 (2009/09/27)
This paper describes the synthesis, pharmacological evaluation and docking studies of a series of new sulindac analogues. Overall, the designed compounds revealed good, in vivo, antinociceptive activity and satisfactory anti-inflammatory profile. Flexible
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions
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, (2008/06/13)
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
INDENYL HYDROXAMIC ACIDS AND HYDROXY UREAS AS INHIBITORS OF 5-LIPOXYGENASE
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, (2008/06/13)
Compounds having the formula I: are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platel
