Asymmetric synthesis of Sulindac esters by enantioselective sulfoxidation in the presence of chiral titanium complexes

Article abstract of DOI:10.1016/j.tetasy.2006.12.002

High ee values (up to 94-96% ee) and moderate isolated yields (48-50%) were achieved in the preparation of Sulindac alkyl esters. These molecules are simple and straightforward precursors of Sulindac, an anti-inflammatory drug that has also been recently