141748-64-3Relevant academic research and scientific papers
A one-pot process for palladium catalyzed direct C-H acylation of anilines in water using a removable ortho directing group
Szabo, Fruzsina,Simko, Daniel,Novak, Zoltan
, p. 3883 - 3886 (2014/01/06)
A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.
Mild palladium-catalyzed oxidative direct ortho-C-H acylation of anilides under aqueous conditions
Szabo, Fruzsina,Daru, Janos,Simko, Daniel,Nagy, Tibor Zs.,Stirling, Andras,Novak, Zoltan
, p. 685 - 691 (2013/04/10)
Palladium-catalyzed cross-dehydrogenative coupling between anilides and aromatic aldehydes was achieved under aqueous conditions. A wide variety of the desired benzophenone derivatives was isolated in good to excellent yield. The reaction rate acceleration effect of acid and detergent has been demonstrated. Mechanistic insight has been obtained from quantum chemical calculations. Copyright
