1417551-48-4Relevant academic research and scientific papers
Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents
Singh, Sheo B.,Kaelin, David E.,Wu, Jin,Miesel, Lynn,Tan, Christopher M.,Meinke, Peter T.,Olsen, David,Lagrutta, Armando,Bradley, Prudence,Lu, Jun,Patel, Sangita,Rickert, Keith W.,Smith, Robert F.,Soisson, Stephen,Wei, Changqing,Fukuda, Hideyuki,Kishii, Ryuta,Takei, Masaya,Fukuda, Yasumichi
supporting information, p. 609 - 614 (2014/06/09)
Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to inhibit
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
Miles, Timothy J.,Axten, Jeffrey M.,Barfoot, Christopher,Brooks, Gerald,Brown, Pamela,Chen, Dongzhao,Dabbs, Steven,Davies, David T.,Downie, David L.,Eyrisch, Susanne,Gallagher, Timothy,Giordano, Ilaria,Gwynn, Michael N.,Hennessy, Alan,Hoover, Jennifer,Huang, Jianzhong,Jones, Graham,Markwell, Roger,Miller, William H.,Minthorn, Elizabeth A.,Rittenhouse, Stephen,Seefeld, Mark,Pearson, Neil
, p. 7489 - 7495 (2012/02/04)
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.
Antibacterial Agents
-
Page/Page column 10, (2008/12/07)
Naphthalene, quinoline, quinoaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 21; 22, (2010/11/25)
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 16, (2008/06/13)
Naphthyridine and quinoline derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 19, (2008/06/13)
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 22, (2008/06/13)
Naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 20, (2008/06/13)
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 20, (2008/06/13)
Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
ANTIBACTERIAL AGENTS
-
Page/Page column 67-68, (2010/02/15)
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
