14176-50-2

Usage

Uses

Used in Veterinary Medicine:
Tiletamine Hydrochloride (200 MG) is used as an anesthetic agent for veterinary applications, particularly in the induction of anesthesia in animals. It is often combined with other drugs to provide a balanced anesthetic regimen, ensuring a smooth and controlled induction and recovery process.
Used in Human Medicine:
In human medicine, Tiletamine Hydrochloride (200 MG) is used as a component of an anesthetic cocktail, often in combination with other drugs to provide sedation, analgesia, and amnesia during medical procedures. Its use in human medicine is typically limited to specific cases due to its potential side effects and the availability of alternative anesthetic agents.
Used in Research:
Tiletamine Hydrochloride (200 MG) is also utilized in research settings to study the effects of anesthetic drugs on the central nervous system. It helps researchers understand the mechanisms of action of anesthetic agents and develop new drugs with improved safety and efficacy profiles.
Used in Drug Formulation:
As a pharmaceutical compound, Tiletamine Hydrochloride (200 MG) is used in the formulation of anesthetic drugs for various applications, including veterinary and human medicine. Its formulation allows for controlled release and targeted delivery of the drug, ensuring optimal therapeutic effects and minimizing side effects.

Indications

Tiletamine hydrochloride/zolazepam hydrochloride is used for chemical immobilization and surgical anesthesia in a wide variety of carnivores, artiodactylids, birds, reptiles, and amphibians.

Veterinary Drugs and Treatments

Telazol? is indicated for restraint or anesthesia combined with muscle relaxation in cats, and for restraint and minor procedures of short duration (≈30 minutes) which require mild to moderate analgesia in dogs. Although not officially approved, it has been used also in horses and many exotic and wild species.

Mode of action

Tiletamine hydrochloride is a dissociative anesthetic agent whose pharmacologic action is characterized by profound analgesia, normal pharyngeal-laryngeal reflexes and cataleptoid anesthesia. Used alone, tiletamine hydrochloride does not provide adequate muscle relaxation for abdominal surgical procedures. When combined with zolazepam hydrochloride, good muscle relaxation is generally attained during the phase of deep surgical anesthesia. Tilzolan is a rapid-acting anesthetic combination of tiletamine hydrochloride and zolazepam hydrochloride.

InChI:InChI=1/C12H17NOS.ClH/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14;/h5,7,9,13H,2-4,6,8H2,1H3;1H

Upstream product

• 14176-49-9 Tiletamine 

Relevant academic research and scientific papers

Sequential [3,3]-Sigmatropic Rearrangement/Nucleophilic Arylation of N -(Benzoyloxy)enamides towards the Preparation of Cyclic β-Aryl-β-amino Alcohols

A new method has been developed for the efficient synthesis of cyclic β-aryl-β-amino alcohol derivatives bearing a tetrasubstituted carbon center via the [3,3]-sigmatropic rearrangement of N-(benzoyl oxy)enamides followed by nucleophilic arylation reactio

Synthesis of cyclopentyl 2-thienyl ketone, tiletamine and tiletamine acid addition salts, such as tiletamine hydrochloride

A water-scavenging solvent, such a polyphosphoric acid, can be used for the synthesis of cyclopentyl 2-thienyl ketone by the direct acylation of cyclopentanecarboxylic acid without first reacting the cyclopentanecarboxylic acid with thionylchloride to form the acid chloride, while achieving new and unexpected yields. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone, aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine, and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.

Synthesis of cyclopentyl 2-thienyl ketone tiletamine and tiletamine acid addition salts such as tiletamine hydrochloride

Solid, non-tin-containing catalysts can be used for the synthesis of cyclopentyl 2-thienyl ketone by the reaction of cyclopentanecarboxylic acid chloride and thiophene, while achieving new and unexpected yields. Aluminum trichloride is both cheaper than stannic chloride and it is easier to deal with as a waste stream. The successful use of graphite as a catalyst for the reaction of cyclopentanecarboxylic acid chloride and thiophene provides a mild and ecologically friendly method for carrying out the Friedel-Crafts reaction. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone; aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine; and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.