141764-84-3

Upstream product

• 718-08-1 ethyl 3-oxo-4-phenylbutyrate 
• 141764-74-1 2-(2-Benzenesulfinyl-ethyl)-3-oxo-4-phenyl-butyric acid ethyl ester 
• 109-92-2 ethyl vinyl ether 
• 188475-11-8 ethyl 2-diazo-3-carbonyl-4-phenylbutyrate 
• 108-05-4 vinyl acetate 
• 141764-80-9 2-Benzyl-5-phenylsulfanyl-4,5-dihydro-furan-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Rhodium-catalyzed synthesis of 2,3 – Disubstituted N-methoxy pyrroles and furans via [3+2] cycloaddition between metal carbenoids and activated olefins

For the first time, we report the synthesis of 2-substituted N-alkoxy pyrrole 3-carboxylate and furan 3-carboxylate via Rh-catalyzed [3+2] cycloaddition between α-diazo oxime ether or α-diazo carbonyl compounds with vinyl equivalents in a one-pot process. We have demonstrated ethyl vinyl ether as well as vinyl acetate as vinyl equivalents and both were found to give excellent yields. We have also demonstrated the synthesis of N-alkoxy dihydropyrrole derivatives by carrying out the reaction at low temperature.

Unsaturated Sulfoxides in Organic Synthesis: A New General Furan Synthesis

Furans have been efficiently synthesised by a three-step reaction sequence.Michael addition of keto esters to alkenyl sulfoxides followed by Pummerer rearrangement afforded the cyclic intermediates 11 in good yield.Treatment of the latter with 3-chloroperoxybenzoic acid led by oxidation and syn-elimination of the corresponding sulfoxide, to substituted furans.