141774-68-7

Basic information

• Product Name: (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
• Synonyms: (2S)-2-AMINOMETHYL-1-BENZYLOXYCARBONYLPYRROLIDINE;REF DUPL: (S)-2-Aminomethyl-1-N-Cbz-pyrrolidine;benzyl (2S)-2-(aMinoMethyl)pyrrolidine-1-carboxylate;S-1-CBZ-2-aMinoMethyl pyrrolidine-HCl;(2S)-2-(aminomethyl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester
• CAS NO: 141774-68-7
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.3
• Mol File: 141774-68-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 370.5 °C at 760 mmHg
• Flash Point: 177.9 °C
• Appearance: /
• Density: 1.155 g/cm³
• Storage Temp.: 2-8°C
• PKA: 9.91±0.29(Predicted)
• CAS DataBase Reference: (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE(141774-68-7)
• EPA Substance Registry System: (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE(141774-68-7)

Safety Data

• Hazardous Substances Data: 141774-68-7(Hazardous Substances Data)

Usage

General Description

"(S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE, also known as (S)-benzyl 2-(aminomethyl)pyrrolidine-1-carboxylate, is a chemical compound typically used in the field of organic chemistry. As a chemical, it takes the form of a pale yellow to beige crystalline powder. It has a complex molecular structure with the formula C14H18N2O2. Key properties include a molecular weight of 246.304 g/mol and a melting point range of 90-94 degrees Celsius. Its primary use is as a reagent in the synthesis of other organic compounds, particularly in the pharmaceutical industry where it is used to create a variety of medicines. Safety precautions should be adhered to when handling this chemical as with any other laboratory reagents.

Upstream product

• 141774-67-6 (S)-benzyl 2-(azidomethyl)pyrrolidine-1-carboxylate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 34079-31-7 Z-Pro-NH₂ 
• 63808-36-6 (2S)-2-cyanopyrrolidine-1-carboxylic acid benzyl ester 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 72500-24-4 (2S)-2-(4-methylphenylsulfonyloxymethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 6216-63-3 N-Cbz-Prolinol 

Downstream Products

• 1172596-79-0 benzyl (S)-2-(isothiocyanatomethyl)pyrrolidine-1-carboxylate 
• 1206881-76-6 (S)-benzyl 2-((N,N-diphenylphosphinamido)methyl)pyrrolidine-1-carboxylate 
• 1393378-00-1 (S)-2-((pyridin-2-ylmethylamino)methyl)-1-N-Cbz-pyrrolidine 
• 1393378-01-2 (S)-2-((6-methyl-pyridin-2-ylmethylamino)methyl)-1-N-Cbz-pyrrolidine 
• 1393378-02-3 (S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate 
• 1393378-03-4 (S)-benzyl 2-((methyl((6-methylpyridin-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate 
• 1599474-01-7 (S)-benzyl 2-(((3aR,5S,6R,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamido)methyl)pyrrolidine-1-carboxylate 
• 1599474-00-6 (S)-benzyl 2-(((3aR,5S,6R,6aR)-6-azido-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamido)methyl)pyrrolidine-1-carboxylate 
• 1474047-58-9 benzyl (S)-2-({(1S,2S,3R,5S)-2-[(tert-butoxycarbonyl)amino]-2,6,6-trimethylbicyclo[3.1.1]heptan-3-ylcarboxamido}methyl)pyrrolidine-1-carboxylate 
• 853934-65-3 (S)-N-(pyrrolidin-2-ylmethyl)benzamide 
• 1419208-73-3 benzyl (S)-2-(benzamidomethyl)pyrrolidine-1-carboxylate 
• 1419208-74-4 benzyl (S)-2-(pivalamidomethyl)pyrrolidine-1-carboxylate 
• 1321848-92-3 benzyl (S)-2-((3-(3,5-bis(trifluoromethyl)phenyl)thioureido)methyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Apoptotic protein inhibitor as well as preparation method and application thereof

The invention relates to a compound with a structure as shown in a formula I which is described in the specification, a racemate, a stereoisomer, a tautomer, an isotope marker, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, a prodrug or

Synthesis of chiral NADH analog based on proline template including thiourea and nicotinic acid moieties

Chiral reductase-mimicking organic molecule built on proline template incorporating a covalently bound NADH mimic via thiourea, and related reducing agent Hantzsch dihydropyridine, was designed. A synthetic path was developed involving interlinking of chiral proline derivatives with thiourea and subsequent coupling reaction with nicotinoyl chloride. The structure of target compound was studied by x-ray, indicating a double H bond with thiourea hydrogens and oxygen O1 of benzylcarbamate fragment. The reduction of benzil and imines was performed. Taylor & Francis Group, LLC.

N-urethane-protected amino alkyl isothiocyanates: Synthesis, isolation, characterization, and application to the synthesis of thioureidopeptides

(Chemical Equation Presented) Synthetically useful N-Fmoc amino-alkyl isothiocyanates have been described, starting from protected amino acids. These compounds have been synthesized in excellent yields by thiocarbonylation of the monoprotected 1,2-diamines with CS2/TEA/p-TsCl, isolated as stable solids, and completely characterized. The procedure has been extended to the synthesis of amino alkyl isothiocyanates from Boc- and Z-protected amino acids as well. The utility of these isothiocyanates for peptidomimetics synthesis has been demonstrated by employing them in the preparation of a series of dithioureidopeptide esters. Boc-Gly-OH and Boc-Phe-OH derived isothiocyanates 9a and 9c have been obtained as single crystals and their structures solved through X-ray diffraction. They belong to the orthorhombic crystal system, and have a single molecule in the asymmetric unit (Z′ = 1). 9a crystallizes in the centrosymmetric space group Pbca, while 9c crystallizes in the noncentrosymmetric space group P212121.