853934-65-3Relevant articles and documents
Systematic evaluation of a few proline derivatives as catalysts for a direct aldol reaction
Sutar, Revannath L.,Joshi, Navalkishore N.
, p. 43 - 49 (2013/02/23)
A series of pyrrolidine derivatives were prepared and examined as catalysts for an aldol reaction. Structural variations in these molecules involved altering the sterics at the α-position, the position of the carbonyl group, and the acidities of the hydrogen bonding sites. The effect of these factors on catalytic activity and enantioselectivity was studied. The experimental results revealed that additional sterics at the α-position were detrimental. However, no correlation was found between the catalytic activity and N-H acidity.
The reversed binding of β-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors
Nordhoff, Sonja,Cerezo-Galvez, Silvia,Feurer, Achim,Hill, Oliver,Matassa, Victor G.,Metz, Guenther,Rummey, Christian,Thiemann, Meinolf,Edwards, Paul J.
, p. 1744 - 1748 (2007/10/03)
The co-crystal structure of β-phenethylamine fragment inhibitor 5 bound to DPP-IV revealed that the phenyl ring occupied the proline pocket of the enzyme. This finding provided the basis for a general hypothesis of a reverse binding mode for β-phenethylam
