1417897-52-9

Upstream product

• 98-01-1 furfural 
• 931-53-3 Cyclohexyl isocyanide 
• 116847-33-7 2-azido-3-phenyl-propionic acid 
• 106-47-8 4-chloro-aniline 
• 2101-86-2 p-methylazidobenzene 
• 1417897-40-5 5-methyl-N-(prop-2-ynyl)-1-(p-tolyl)-1H-1,2,3-triazole-4-carboxamide 

Relevant academic research and scientific papers

Chemoselective preparation of unsymmetrical bis(1,2,3-triazole) derivatives and application in bis(1,2,3-triazole)-modified peptidomimetic synthesis

An efficient chemoselective methodology for the syntheses of unsymmetrical bis(1,2,3-triazole) derivatives has been developed. This protocol utilizes alkynyl-substituted amines as bifunctional linkers to conjoin a copper-free three-component cycloaddition with a copper(I)-catalyzed alkyne-azide cycloaddition in a one-pot procedure. In addition, we used this method for the construction of unsymmetrical bis(1,2,3-triazole)-modified peptidomimetics through a combination of multicomponent reactions taking place in a sequential process, which may be utilized in biological applications. A protocol for the syntheses of unsymmetrical bis(1,2,3-triazole) derivatives has been reported, which utilizes alkynyl-substituted amines as bifunctional linkers to conjoin a copper-free three-component cycloaddition with a copper(I)-catalyzed alkyne-azide cycloaddition in a one-pot procedure. This method was then used to construct unsymmetrical bis(1,2,3-triazole)-modified peptidomimetics. Copyright