141823-14-5Relevant articles and documents
A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties
Canale, Vittorio,Grychowska, Katarzyna,Kurczab, Rafa?,Ryng, Mateusz,Keeri, Abdul Raheem,Sata?a, Grzegorz,Olejarz-Maciej, Agnieszka,Koczurkiewicz, Paulina,Drop, Marcin,Blicharz, Klaudia,Piska, Kamil,P?kala, El?bieta,Janiszewska, Paulina,Krawczyk, Martyna,Walczak, Maria,Chaumont-Dubel, Severine,Bojarski, Andrzej J.,Marin, Philippe,Popik, Piotr,Zajdel, Pawe?
, (2020)
The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) anta
Synthesis mesomorphic and theoretical studies of some new unsymmetrical dimeric ethers of 6-amino-1,3-dimethyluracil and biphenyl cores
Mohammad, AbdulKarim-Talaq,Srinivasa,Mohammed, Hameed Madlool,Hariprasad,Yeap, Guan-Yeow
, p. 201 - 207 (2016)
New sets of unsymmetric calamitic molecules with uracil unit at one end and biphenyl core at another end were synthesized. Liquid crystal property of these molecules was investigated by POM and DSC techniques. All compounds exhibit LC property depending o
Redox-responsive Fluorescent Nanoparticles Based on Diselenide-containing AIEgens for Cell Imaging and Selective Cancer Therapy
Han, Wenkun,Zhang, Song,Qian, Jingyu,Zhang, Jianxu,Wang, Xuanhang,Xie, Zhigang,Xu, Bin,Han, Yanqiu,Tian, Wenjing
, p. 1745 - 1753 (2019)
A fluorescent, diselenide-containing 9,10-distyrylanthracene (DSA) derivative (SeDSA) with aggregation-induced emission (AIE) characteristic was successfully synthesized and SeDSA nanoparticles (NPs) were prepared through a nanoprecipitation method. SeDSA
A Cyclic Ruthenium Benzylidene Initiator Platform Enhances Reactivity for Ring-Expansion Metathesis Polymerization
Wang, Teng-Wei,Huang, Pin-Ruei,Chow, Jayme L.,Kaminsky, Werner,Golder, Matthew R.
supporting information, p. 7314 - 7319 (2021/05/26)
Ring-expansion metathesis polymerization (REMP) has shown potential as an efficient strategy to access cyclic macromolecules. Current approaches that utilize cyclic olefin feedstocks suffer from poor functional group tolerance, low initiator stability, and slow reaction kinetics. Improvements to current initiators will address these issues in order to develop more versatile and user-friendly technologies. Herein, we report a reinvigorated tethered ruthenium-benzylidene initiator, CB6, that utilizes design features from ubiquitous Grubbs-type initiators that are regularly applied in linear polymerizations. We report the controlled synthesis of functionalized cyclic poly(norbornene)s and demonstrate that judicious ligand modifications not only greatly improve kinetics but also lead to enhanced initiator stability. Overall, CB6 is an adaptable platform for the study and application of cyclic macromolecules via REMP.
Ink Composition and Method for Manufacturing Organic Light Emitting Device
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Paragraph 0215; 0218-0219, (2021/02/19)
The present specification relates to an ink composition including: a compound represented by Formula 1; and a solvent represented by the Formula 2, and a method for manufacturing an organic light emitting device formed by using the ink composition.
Synthesis of hantzsch adducts as cholinesterases and calcium flux inhibitors, antioxidants and neuroprotectives
Angona, Irene Pachón,Martin, Helene,Daniel, Solene,Moraleda, Ignacio,Bonet, Alexandre,Wnorowski, Artur,Maj, Maciej,Jozwiak, Krzysztof,Iriepa, Isabel,Refouvelet, Bernard,Marco-Contelles, José,Ismaili, Lhassane
, p. 1 - 19 (2020/10/29)
We report herein the design, synthesis, biological evaluation, and molecular modelling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((5-aminoalkyl)oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3a-p, have been obtained via Hantzsch reaction from appropriate and commercially available precursors. Pertinent biological analysis has prompted us to identify MTDL 3h [dimethyl-4-(4-((5-(4-benzylpiperidin-1-yl)pentyl)oxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate] as an attractive inhibitor of AChE (1.8 μM) and BuChE (2 μM), Ca+2 channel antagonist (47.72% at 10 μM), and antioxidant (2.54 TE) agent, showing significant neuroprotection 28.68% and 38.29% against H2 O2, and O/R, respectively, at 0.3 μM, thus being considered a hit-compound for further investigation in our search for anti-Alzheimer’s disease agents.
