1418269-60-9

Basic information

• Product Name: C₁₄H₁₁N₅
• Synonyms: C₁₄H₁₁N₅
• CAS NO: 1418269-60-9
• Molecular Weight: 249.275
• Mol File: 1418269-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₁N₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₁N₅(1418269-60-9)
• EPA Substance Registry System: C₁₄H₁₁N₅(1418269-60-9)

Safety Data

• Hazardous Substances Data: 1418269-60-9(Hazardous Substances Data)

Upstream product

• 55557-52-3 2-chloro-3-cyanopyrazine 
• 6863-74-7 6-chloropyrazine-2-carbonitrile 
• 98-96-4 pyrazinamide 
• 918410-50-1 3-chloropyrazine-2,5-dicarbonitrile 
• 104-84-7 para-methylbenzylamine 
• 132274-79-4 3-chloro-5-cyano-2-pyrazinecarboxamide 

Relevant articles and documents

Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution

A series of 19 new compounds related to pyrazinamide were synthesized, characterized with analytical data and screened for in vitro whole cell antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium kansasii and two types of Mycobacterium avium. The series consisted of 3-(benzylamino)-5-cyanopyrazine-2-carboxamides and 3-(benzylamino)pyrazine-2,5-dicarbonitriles with various substituents on the phenyl ring. RP-HPLC method was used to determine the lipophilicity of the prepared compounds. Nine compounds exerted similar or better activity against Mycobacterium tuberculosis compared to pyrazinamide (MIC = 6.25-12.5 μg/mL). 3-(Benzylamino)pyrazine-2,5-dicarbonitrile inhibited all of the tested mycobacterial strains with MIC within the range 12.5-25 μg/mL. Although not the most active, 4-NH2 substituted compounds possessed the lowest in vitro cytotoxicity (hepatotoxicity), leading to selectivity index SI = 5.5 and SI >21.