1418318-99-6

Basic information

• Product Name: C₁₃H₁₉NO₅S
• Synonyms: C₁₃H₁₉NO₅S
• CAS NO: 1418318-99-6
• Molecular Weight: 301.364
• Mol File: 1418318-99-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₉NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₉NO₅S(1418318-99-6)
• EPA Substance Registry System: C₁₃H₁₉NO₅S(1418318-99-6)

Safety Data

• Hazardous Substances Data: 1418318-99-6(Hazardous Substances Data)

Upstream product

• 856408-80-5 (R)-N-ethyl-N-methylcarbamic acid-3-(1-hydroxyethyl)phenyl ester 
• 124-63-0 methanesulfonyl chloride 
• 855300-09-3 1-(N-ethyl-N-methylaminocarbonyloxy)-3-acetylbenzene 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 123441-03-2 rivastigmin 

Relevant articles and documents

Industrial scale-up of enantioselective hydrogenation for the asymmetric synthesis of rivastigmine

Two efficient processes for the synthesis of rivastigmine, one of the most potent drugs for the treatment of mild-to-moderate dementia of the type presenting in Alzheimer's disease, has been developed. Of particular note is the processes used for the asymmetric hydrogenation by applying the highly efficient chiral spiro catalyst, Ir-SpiroPAP. The first route was easy to scale up in industry and provided the commercial intermediate (S)-3-(1- dimethylaminoethyl)phenol, 6, which is suitable for the manufacture of rivastigmine in active pharmaceutical ingredient (API) demand. The second route was convenient for operation and purification and completed the synthesis of rivastigmine (1) in four steps and 84% overall yield.