141836-50-2

Basic information

• Product Name: [4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]methanol
• Synonyms: [4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]methanol ;4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]cyclohexaneMethanol;CyclohexaneMethanol, 4-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-
• CAS NO: 141836-50-2
• Molecular Formula: C₁₄H₃₀O₂Si
• Molecular Weight: 258.4723
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 141836-50-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]methanol(141836-50-2)
• EPA Substance Registry System: [4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]methanol(141836-50-2)

Safety Data

• Hazardous Substances Data: 141836-50-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

Upstream product

• 105-08-8 bis-1,4-(hydroxymethyl)cyclohexane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 13380-84-2 4-(hydroxymethyl)cyclohexane-1-carboxylic acid 
• 124-38-9 carbon dioxide 

Downstream Products

• 129830-38-2 (-)-Y-27632 
• 786659-19-6 {1-[4-(pyridin-4-ylcarbamoyl)-cyclohexyl]-but-3-enyl}-carbamic acid tert-butyl ester 
• 671816-04-9 trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 
• 672314-45-3 (1R,1'R)-N-[1'-(phenyl)ethyl]-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-53-3 (1S,1'S)-N-[1'-(phenyl)ethyl]-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-58-8 (R)-N-tert-butyloxycarbonyl-1-[4'-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-59-9 (S)-N-tert-butyloxycarbonyl-1-[4'-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 

Relevant articles and documents

NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF

The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.

IMIDAZOLE COMPOUND

Disclosed is an imidazole compound, in particular, the compound as shown in formula (I) and a pharmaceutically acceptable salt or tautomer thereof are disclosed.

Facile cleavage of silyl protecting groups with catalytic amounts of FeCl3

A very mild and environmentally benign method for removal of silyl protecting groups using catalytic amounts of iron ion in MeOH is presented. The method is particularly effective for cleaving triethylsilyl (TES) protecting groups. Georg Thieme Verlag Stuttgart.