672314-45-3 Usage
Uses
Used in Pharmaceutical Industry:
(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine is used as an intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Its unique structure allows it to modulate cellular processes and signal transduction pathways, making it a valuable component in the development of drugs targeting specific protein kinases and neuronal growth factors.
As an intermediate in the synthesis of Rho kinase inhibitors, (1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine contributes to the development of therapeutic agents that can regulate the activity of Rho kinases, which are involved in various cellular functions, including cytoskeletal organization, cell migration, and cell proliferation. Inhibition of Rho kinases has been implicated in the treatment of various diseases, such as cancer, cardiovascular disorders, and neurological conditions.
Furthermore, as a precursor to neurite outgrowth promoters, (1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine plays a role in the enhancement of neuronal growth and regeneration. This application is particularly relevant in the context of neurodegenerative diseases and conditions involving nerve damage, where promoting neurite outgrowth can contribute to the restoration of neuronal function and tissue repair.
Check Digit Verification of cas no
The CAS Registry Mumber 672314-45-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,2,3,1 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 672314-45:
(8*6)+(7*7)+(6*2)+(5*3)+(4*1)+(3*4)+(2*4)+(1*5)=153
153 % 10 = 3
So 672314-45-3 is a valid CAS Registry Number.
672314-45-3Relevant academic research and scientific papers
Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl) cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters
Gingras, Karine,Avedissian, Hovsep,Thouin, Eryk,Boulanger, Véronique,Essagian, Charles,McKerracher, Lisa,Lubell, William D.
, p. 4931 - 4934 (2007/10/03)
The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R = Me] was examined by the synthesis of (+)- and (-)-1, and two alkyl chain analogs (+)- and (-)-2 (R = n-propyl) and (-)-3 (R = n
1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES
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Page 82; 83, (2010/02/06)
Allylic compounds represented by the formula (I) are provided, wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.
