141847-50-9

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 191849-74-8 Trifluoro-methanesulfonic acid (2S,4R)-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-1-methylene-hept-6-ynyl ester 
• 161055-34-1 (E)-(S)-5-(tert-Butyl-dimethyl-silanyloxy)-oct-2-en-7-yn-1-ol 
• 161055-40-9 (3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-oct-1-en-7-yn-3-ol 
• 161055-38-5 tert-Butyl-[(R)-1-((2S,3R)-3-iodomethyl-oxiranylmethyl)-but-3-ynyloxy]-dimethyl-silane 
• 161055-33-0 (S,E)-5-(tert-butyldimethylsilyloxy)-8-(trimethylsilyl)oct-2-en-7-yn-1-ol 
• 127760-25-2 2-((S)-4-Oxiranyl-but-2-ynyloxy)-tetrahydro-pyran 
• 191849-78-2 (1S,2S,4S,6R)-1-Methyl-7-oxa-bicyclo[4.1.0]heptane-2,4-diol 
• 121289-20-1 (1S,2S,4R,6R)-2,4-bis(tert-butyldimethylsilyloxy)-1-methyl-7-oxabicyclo[4.1.0]heptane 
• 161055-42-1 (5R,7S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-non-8-en-2-ynoic acid methyl ester 
• 191849-75-9 Acetic acid (1R,3S,5S,6S)-5-hydroxy-6-methyl-7-oxa-bicyclo[4.1.0]hept-3-yl ester 
• 161167-56-2 {(2S,3S)-3-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-oxiranyl}-methanol 
• 161055-37-4 {(2S,3S)-3-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-pent-4-ynyl]-oxiranyl}-methanol 

Downstream Products

• 227961-42-4 [3S-(1E,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethanol 

Relevant academic research and scientific papers

Efficient and versatile synthesis of A-ring precursors of 1α,25-dihydroxyvitamin D3 and analogues. Application to the synthesis of Lythgoe-Roche phosphine oxide

An efficient, versatile synthesis of Lythgoe-Phosphine Oxide has been developed starting from l-carvene. The key steps are rupture of protected epoxide 7 to give dicarbonyl compound 8, preparation of vinylic triflate 2, and palladium-catalysed cyclization-carbonylation of vinylic triflate 2.

Vitamin D3 analogs

Compounds of the formula wherein R1is hydrogen or an alkyl group; R2is hydrogen or an alkyl group; or R1, R2and C20together are cyclopropyl; R3is alkyl, hydroxy-alkyl or fluoroalkyl; and R

Enantioconvergent Preparation of the A-Ring Precursors of Calcitriol from Either (R)- or (S)-Epichlorohydrin

Linear and cyclic A-ring precursors of calcitriol have been prepared in both synthetically and enantiomerically convergent ways starting from either (R)- or (S)-epichlorohydrin.